Uridine: A Holy Grail of Nootropics

Discovering nootropic supplements sometimes feels like finding a holy grail. When a compound benefits our mental and physical health, it is exhilarating. One of these smart supplements is Uridine Monophosphate.

Uridine has exhibited positive effects for cognition and learning, Alzheimer’s Disease, Bipolar Disorder, and cardiac health.

Although the research on uridine’s role in improving cognition is not extensive because it has not been studied widely in this capacity, there is a study performed which displayed significant improvements on human subjects in an array of cognitive tests. Memory, visual learning, execution of executive functioning, and cognitive flexibility drastically improved in a combination of nootropics incorporating uridine (Richter, 2011).

One may ask why Uridine may boost cognition with such effectiveness, and the answer if fairly well-known. Uridine is found to have positive benefits on both synaptic function and neural outgrowth.

Uridine confers benefits upon synaptic functions by increasing brain phosphatidylcholine levels, a primary constituent of dendrite membranes. At least two studies have fed animal models uridine, and have observed that indeed it leads to the formation and functioning of synapses. As a caveat, the studies also combined fish oil and choline with the uridine, resulting in this potent synergistic effect. Cognitive enhancements were also noted as an enhanced release of neurotransmitters. (Wurtman, 2009)

Yet just as important as our cognitive health and the maintenance of our general intellectual aptitude, is our mental health. Here too, uridine shines forth. A six week study observed that uridine supplementation for bipolar disorder in adolescents resulted in a significant positive effect on subjects in comparison with baseline depressive symptoms, prompting researchers to call for more systematic studies (Kondo, 2011).

Moreover, in considering if uridine is right for us, we should weigh the evidence of its effects on physical health outside of its involvement with the brain. Again, uridine looks like a winner – with a vital role as a potential agent of anti-ischemic mechanisms. Indeed, experiments conducted on an animal model displayed that uridine affects stability in energy metabolism in the heart following an hour-long occlusion of the left coronary artery. (Krylova, 2012)

Fortunately, uridine is not as evasive as the legendary grail, and it is made readily available by high quality companies like Double Wood Supplements. The reasons for incorporating uridine in your nootropic stack are many and diverse, of which I have only highlighted some of the major features that give uridine a magnetic appeal to anyone who is concerned about brain health, mental health, and their overall health.

Double Wood Uridine

References and Works Cited

Richter Y, Herzog Y, Eyal I, Cohen T. Cognitex supplementation in elderly adults with memory complaints: an uncontrolled open label trial. J Diet Suppl. 2011 Jun;8(2):158-68. doi: 10.3109/19390211.2011.569514. PMID: 22432687.

Wurtman RJ, Cansev M, Sakamoto T, Ulus IH. Use of phosphatide precursors to promote synaptogenesis. Annu Rev Nutr. 2009;29:59-87. doi: 10.1146/annurev-nutr-080508-141059. PMID: 19400698.

Kondo DG, Sung YH, Hellem TL, et al. Open-label uridine for treatment of depressed adolescents with bipolar disorder. J Child Adolesc Psychopharmacol. 2011;21(2):171-175. doi:10.1089/cap.2010.0054

Krylova IB, Bulion VV, Selina EN, Mironova GD, Sapronov NS. Effect of uridine on energy metabolism, LPO, and antioxidant system in the myocardium under conditions of acute coronary insufficiency. Bull Exp Biol Med. 2012 Sep;153(5):644-6. doi: 10.1007/s10517-012-1787-4. PMID: 23113246.

By |2021-02-09T02:23:15+00:00February 2nd, 2021|

About the Author:

A long-time nootropics enthusiast who is fascinated with the prospect of cognitive enhancement, John Ryan is an independent writer who received his University education at Northern Michigan University, as a history major, where he was inducted into the Phi Beta Kappa Society for academic excellence. While in Michigan, he also trained as an athlete at the United States Olympic Education Center, where he achieved the status of a multiple-time University All-American in Greco-Roman wrestling. He has authored several plays and a collection of poetry.