Nootropics in the Long Run

What’s the best brain supplement?

The one that works the longest!

It’s the one that keeps helping you improve day after day for years on end.

I haven’t seen Limitless, but smart drug (nootropics) enthusiasts like to talk about it. It’s a nice fantasy; a pill lets a guy learn anything instantly, which for some reason upsets Robert Deniro.

That’s my impression from the trailer, anyway.

We can forgive a movie for not being realistic. What’s sad is it’s not that different from real products we see claiming to blast away seven layers of stomach fat while giving you bicep peaks that would put Everest and Kiliminjaro to shame – all in thirty days or less.

There’s no doubt some supplements make people feel a lot sharper. A cup of coffee (a decent long-term nootropic, but more on that later) can help you work and give you confidence. But thinking you’re brilliant and being brilliant are two different ball games.

You want compound returns, like what you’d get from a good investment. You want something with an extensive and scientifically validated track record of making your brain better.

I’ve known day traders who’ve taken chemicals like oxiracetam (washing it down with espresso) by the handful (maybe with prescription stimulants), but do you think you can do that every day for long?

Do you think they’re in it for their health?

I noticed a lot of people in the nootropics community were buying products manufactured overseas that were not labeled for human consumption. Others might have been getting pharmacy grade stuff, but were experimenting with substances that had little to no history of human use.

In other words, they’re treating themselves like guinea pigs.

Now, they’re free to make their own choices. Most of us, though, aren’t interested in exploring unknown territory when our brains and bodies are at stake. What are the long term effects? Some noots might be good for kicking out a term paper or vacuuming the living room, but what about twenty years from now?

I’ll spare you the cliches about time being fair or unfair. Whatever it is, it’s definitely impartial and, by most accounts, moves faster than most of us think it will. There’s a time and place for quick fixes, but there will be a time when an energy drink won’t even put us in second gear. Not much can happen when the engine is rusted out.

What do we do?

Let’s take BDNF, for example.

BDNF (brain-derived neurotrophic factor) isn’t a supplement. It’s a naturally occurring protein that is critical to mood and memory. Exercise and certain foods can raise BDNF, but the effects aren’t immediately noticeable.

As we can see by the chart above, Rise coffee blows the competition away. Besides being higher quality than most of the “mushroom coffees” on the market, it uses a peer-reviewed and patented product for its extract. Not many brands can say that.

We can say the same for MasterMind.™ Produced in cGMP facilities with USDA organic ingredients, MasterMind was made for peak performers who want to keep getting better at whatever they’re doing

Some of MM’s ingredients, like green tea extract, give an immediate lift, but the blends, which synergize with each other, provide a steady and calm focus. The others are amino acids that increase nitric oxide, something that appears to turn us into super learners like the guy from Limitless.

Steve Kotler mentions the importance of nitric oxide in The Rise of Superman. The book isn’t about any caped man, but snowboarders, surfers, skaters, and other extreme athletes who continue to surpass what was thought possible.

We at NootritionHub want to help you push the envelope of what you thought was possible. More importantly, we want to see you keep pushing. The name of the game is longevity.

References and Suggested Reading

  1. Allen, S.J., & Dawbarn, D. (2006). Clinical relevance of the neurotrophins and their receptors. Clinical Science, 110(2), 175-191.
  2. Althaus, H.H. (2004). Remyelination in multiple sclerosis: a new role for neurotrophins? Progress In Brain Research, 146, 415-432.
  3. Chaldakov, G.N., Tonchev, A.B., & Aloe, L. (2009). NFG and BDNF: from nerves to adipose tissue, from neurokines to metabokines. Rivista Di Psichiatria, 44(2), 79-87.
  4. Lai, P.L., Naidu, M., Sabaratnam, V., Wong, K.H., David, R.P., Kuppusamy, U.R., Abdullah, N., & Malek, S.N. (2013). Neurotrophic properties of the Lion’s mane medicinal mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia. Int J Med Mushrooms, 15(6), 539- 554.
  5. Mori, K., Inatomi, S., Ouchi, K., Azumi, Y., & Tuchida, T. (2009). Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial.
  6. Mori, K., Obara, Y., Moriya, T., Inatomi, S., & Nakahata, N. (2011). Effects of Hericium erinaceus on amyloid B(25-35) peptide-induced learning and memory deficits in mice. Biomed Res, 32(1), 67-72.
  7. Nagano, M., Shimizu, K., Kondo, R., Hayashi, C., Sato, D., Kitagawa, K., & Ohnuki, K. (2010). Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake. Biomed Res, 31(4), 231-237.
  8. Tuszynski, M.H., & Blesch, A. (2004). Nerve growth factor: from animal models of cholinergic neuronal degeneration to gene therapy in Alzheimer’s disease. Progress In Brain Research, 146, 441-449.
  9. Tuszynski, M.H., Yang, J.H., Barba, D., U, H.S., Bakay, R.A., Pay, M.M., et al. (2015). Nerve growth factor gene therapy: activation of neuronal responses in Alzheimer disease. JAMA Neurology, 72, 1139-1147.
  10. Villoslada, P., & Genain, C.P. (2004). Role of nerve growth factor and other trophic factors in brain inflammation. Progress In Brain Research, 146, 403-414.
  11. Wong, K.H., Naidu, M., David, R.P., Bakar, R., & Sabaratnam, V. (2012). Neuroregenerative potential of lion’s mane mushroom, Hericium erinaceus (Bull.:Fr.) Pers. (higher Basidiomycetes), in the treatment of peripheral nerve injury. Int J Med Mushrooms, 14(5), 427- 446
By |2020-09-02T22:53:31+00:00September 2nd, 2020|

About the Author:

Adam Alonzi is a writer, biotechnologist, documentary maker, futurist, inventor, programmer, and author of two obscure novels.